The Concoction tree skills include several potions and powders that an alchemist can use/throw to both damage his enemies and strike them with debilitating debuffs. The Muriatic Acid, Aqua Vitae, Ichor and Alkahest skills can either be casted on the caster or an ally to add that type of damage to their weapons, or used to attack an enemy directly for greater damage and additional effects. The effects of skill runes on these four skills may de different depending on if it is used as a buff or an attack (indicated by ''Effect 1/Effect 2'').

**'''Striking Rune Effect''' - ''Effect 1'' - Enemies spasm when struck Caster or ally becomes charged for X seconds, dealing Lightning damage to any enemy that strikes them / ''Effect 2'' - Increases the frequency and damages of spasms.

**'''Hydra Rune Effect''' - Adds % chance to cast an additional Ichor ''Effect 1'' - Each strike on enemy releases small cloud of poison for X seconds. ''Effect 2'' - While potion for no extra costis in air, it leaves behind a trail of poison.

**'''Striking Rune Effect''' - ''Effect 1'' - Each strike on enemy releases small cloud of poison Caster or ally becomes charged for X seconds. , dealing Poison damage to any enemy that strikes them / ''Effect 2'' - While potion is in air, it leaves behind a trail Decreases the duration| of poisoneffect (making it damage faster) when enemy is moving.

The Hex Field tree skills focus on altering reality in order to allow an alchemist to finish his enemies faster and easier. Once a hex field is cast, the glyph representing that hex field floats at the center and projects a faint boundary for the area of effect. Multiple hex fields can be cast -so long as they are not of the same type -but cannot overlap their effects. If a new hex field overlaps an older one, the new one will cancel the effects of part the old hex field it overlaps. Skill rune boosts that affect the caster or allies stats/attack or adds an effect the the enemy only apply while they are within the field.

**'''Viper Rune Effect''' - Enemies slain within field increase caster and allies' attack damage by % for X seconds.**'''Hydra Rune Effect''' - Caster and allies attack X more times with each attack (like Paladin's Zeal).**'''Force Rune Effect''' - Increases the critical strike damage of caster and allies.**'''Striking Rune Effect''' - Enemies are knocked back when the field is initially casted.

**'''Viper Rune Effect''' - Enemies slain within field increase the caster's elemental resistances by % for 10 seconds.**'''Hydra Rune Effect''' - The field sends out a wave attack of X random elemental damage every 3 seconds.**'''Force Rune Effect''' - Enemies' elemental resistances take X seconds to return to previous state after field dissipates.**'''Striking Rune Effect''' - Enemies are slowed by %.

**'''Viper Rune Effect''' - Enemies slain withing field restore X life to caster.**'''Hydra Rune Effect''' - Field multiplies and spreads out as smaller fields for X seconds when original field dissipates.**'''Force Rune Effect''' - Affected area continues to burn for X seconds after field dissipates.**'''Striking Rune Effect''' - Field deals extra Fire damage when initially casted.

**'''Viper Rune Effect''' - Enemies slain by dead spirit increase spirit's duration by X seconds.**'''Hydra Rune Effect''' - Slain enemy has % chance to release 2 spirits.**'''Force Rune Effect''' - Increases the attack of spirits.**'''Striking Rune Effect''' - Enemies receive X Physical damage when health is below 10%.

**'''Viper Rune Effect''' - When enemy dies within field, all other enemies within field receive % damage of killing blow.**'''Hydra Rune Effect''' - Field slowly expands for duration.**'''Force Rune Effect''' - Caster's damage recieved is reduced by %, this does not reduce the damage received by enemies for attacking caster.**'''Striking Rune Effect''' - Enemies receive X physical damage when crossing border of field.

**'''Viper Rune Effect''' - Enemies slain within field release magic missiles at % of field damage that move outward.**'''Hydra Rune Effect''' - Field releases 3 additional after-explosions that decrease in damage by %.**'''Force Rune Effect''' - Increases damage done to demon and undead class enemies.**'''Striking Rune Effect''' - Enemies receive X Arcane damage when trying to leave field.

* '''Chaos''' - Active Skill. Enemies within field lose special abilities, magic resistance, and are silencedsuffer resource burn.

**'''Viper Rune Effect''' - Enemies slain within field store X mana to caster.**'''Hydra Rune Effect''' - Enemies withing field attack each other.**'''Force Rune Effect''' - Enemies receive % damage of their own spell damage.**'''Striking Rune Effect''' - Enemies are silence for X seconds when field is initially casted.

The Phenomenon tree skills covers a wide array of natural Phenomena that the Alchemists have studied. In understanding the nature of these Phenomena, a skilled alchemist can channel them himself, unleashing untold destruction onto his enemies. Skill runes add the most noticeable gameplay variations to this tree.

**'''Viper Rune Effect''' - Slain enemies become fireballs that are levitated towards random nearby enemy to deal X Fire damage.**'''Hydra Rune Effect''' - Caster randomly attacks enemies in path with weapon before landing.**'''Force Rune Effect''' - Increases size and damage of landing explosion.**'''Striking Rune Effect''' - Burn area lingers for X seconds at takeoff and landing areas.

**'''Viper Rune Effect''' - Slain enemies release charged bolts.**'''Hydra Rune Effect''' - Increases the range of effect.**'''Force Rune Effect''' - Increases the damage over time when uninterrupted.**'''Striking Rune Effect''' - Increases the chance to stun enemies and the stun duration.

**'''Viper Rune Effect''' - Slain enemies release burst of flame.**'''Hydra Rune Effect''' - Adds % chance that when burning enemy comes in contact with another enemy, other enemy is ignited for 1/2 duration.**'''Force Rune Effect''' - Burning enemy leaves wake of fire that lasts for X seconds.**'''Striking Rune Effect''' - Other enemies in range receive % Fire damage over time.

**'''Viper Rune Effect''' - Slain enemies' corpses repel enemies, effect lasts X seconds.**'''Hydra Rune Effect''' - Chain lightning spreads to nearby enemies.**'''Force Rune Effect''' - Increases damage by %, enemy is electrified for X seconds.**'''Striking Rune Effect''' - Lightning strike stuns nearby enemies.