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From Diablo Wiki
→Rune Types: Added BlizzCast 8 screenshot-info.
* Energy Rune
* Lethality Rune
* Multistrike Rune(renamed to Hydra Rune?)
* Power Rune
* Striking Rune
* Viper Rune
(Players have spent a lot of time [http://forums.diii.net/showthread.php?p=6871952 thinking up other types of runes], and discussing their potential benefits.)
More runes will almost certainly be added during development as the team thinks of useful types to include in the game. The team won't be adding a lot of odd types of runes, though; D3 Lead Designer Jay Wilson has stressed that runes must add a useful function to multiple types of skills. The D3 Team wants all the runes to be useful to all characters, so they won't add runes that just boost one type of skill, or one character's skills. They have to think up rune bonus properties that work across the board, so there are probably not going to be 50 types of runes. (Utility doesn't equal equality, since not every skill can receive exactly the same level of improvement from every rune.)
==Rune Quality Levels==