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Disintegrate isn't that damaging and has a fairly high mana cost. The power of it comes from the speed; it moves at the speed of light, and unlike the other projectiles in [[Diablo III]], instantly hits anything it's aimed at. This spell is at its best raking through a line of ranged attackers, especially when aimed at enemies on the very edge of the screen. The Disintegrate laser will hit them instantly, while their arrows (or other attacks) must travel across the screen before they become damaging. It's quite possible to cook targets for a second, kill them, and then move before their projectiles reach you.
This might be the best use of this skill late game; even if the damage doesn't scale up to keep it a killer, it could hit anything on the screen, instantly "silencing" enemy mages and summoners. (Depending on how difficult it is to trigger [[Critical hit|crits ]] with Arcane damage.
This spell drains mana and deals damage steadily, at 12 points per second. The disintegrate laser will hit an unlimited number of [[monster]]s at once, dealing 80% of the damage on the target behind the previous one. Basically, it would deal 100% to the first one, 80% to the second, then 64%, 51%, 41%, 33%, etc, so it's still at least partially useful even after five or six enemies.