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* [[Alabaster rune]]: The toads also blind enemies.
* [[Crimson rune]]: Flaming toads add fire damage to their attack.
* [[Golden rune]]: Reduced cost per cast. From PCG issue 221 -- it adds more toads per cast.
* [[Indigo rune]]: Changes the skill to a rain of toads, which fall down on the targeted location.
* [[Obsidian rune]]: One huge frog that uses a sticky tongue to capture and consume monsters in one bite. It spits out the treasure and items. Can eat [[Champions]] (possibly only at higher/highest rune level?), but not [[bosses]] or (presumably) bigger enemies.