Attack
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From Diablo Wiki
Attack is the default control on the left click in Diablo 3, as it was in Diablo 2. Attack causes a character to run to a location, when clicked. It causes the character to attempt a melee attack on a valid target, when clicked.
As was the case in Diablo 2, most characters will want to substitute a more powerful special skill for Attack, at higher levels. Spell casters will likely want to put a ranged attack spell on the left click, so they do not run up to engage in the melee combat for which they are not suited.
- See the Attack page in the Diablo 2 wiki for more details.