As most fantasy worlds, Sanctuary consists of cultures that shares different social traits. For now, the only thing that is known about these is that there is a mutual understanding of languages between the continents, and whether this is due to the fact that people speak multiple languages through their culture, of if there is a "common" language that everyone shares is unknown. Players as well as [[character]]s and [[NPC]]s in the world travel to either site side of their the globe, and can still communicate with people.

Names are more socially inspired though, and country names such as "[[Westmarch]]", and town names such as [[Tristram]], has a clear "Western" reference from our world, as does the architecture. [[Deckard Cain]], is a character name from a person of the west, while "[[Abd al-Hazir]]" is the name of a character from the flourishing East. If everyone shares a "common" language, they still seem to retain their own cultural names.