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[[Diablo III]]'s Runestones are nothing like the '{{iw|runes runes}}' found in [[Diablo II]]. In D2 there are thirty-three kinds of runes, which are small items that have no use on their own, but can be placed in item sockets to add various bonuses to those items, and in certain combinations produce {{iw|Runeword RuneWords}}, which add powerful, predetermined sets of bonuses, provided that the item has precisely the right number of sockets.
Diablo III's runes are socketed into [[skills]], not itemitems. See the [[Gem]]s and [[Socket]]s articles for more details about [[item]] socketing in Diablo III.