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Hydra runes are known to add bounces to a [[Witch Doctor]]'s thrown [[Skull of Flame]] spell and to increase the Chain of the Wizard's [[Electrocute]] spell. Since each rune is (as best we know) going to work with every active [[skill]], the hydra rune would presumably add extra hits to all sorts of other skills.
Skill Runes were disabled at Blizzcon 2009, and have not been seen since 2008, but [[Jay Wilson]] assured the fans that they remain a major game feature. [http://diablo.incgamers.com/blog/comments/jay-wilson-exclusive-full-transcript/]
::'''''Diii.net: '''They’re still being reworked and you don’t have any further comment?
::'''Jay Wilson: '''They’re not being reworked, we had tons of skill runes on the Wizard and the Barbarian but they were so spotty across the entire class we thought it would be more confusing to show them off than to not. So we just disabled them all for the BlizzCon build. But they’re all still there and they work just fine.
==D3 Runes vs. D2 Runes==