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I noticed from the gameplay video that when he places the item in the "left hand slot" labeled in the picture, it actually is put in his right hand, and vice versa.
This is a detailed shot by Vikkz:
(Please note that the area labeled left hand is actually for the right hand and vice-versa)
[[Image:D3-Inventory.jpg|thumb|350px|right|Inventory in [[Diablo 3]].]]