The new Skill Rune system of Diablo 3 will be vastly different than the Diablo 2 runes, as they will no longer be socketed into items, but instead infused into skills directly, and have a much greater gameplay effect.
Energy Rune, Lethality Rune, Multistrike Rune, Power Rune or a Striking Rune
From the different skill trees, we saw spectacular spell effects such as a Meteor Storm, Slow Time or "Electrocute" (more commonly known as "Chain Lightning").
So take a look at the very impressive skill trees of the Wizard:
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