Salene is a noblewoman in Westmarch and she is a descendant of the demon/creature Astrogha (favoured pet of Diablo) which means she has extraordinary abilities.
Background
She is the widow of Riordan Nesardo and sister to Sardak.
She has a faithful servant named Polth.
Salene is also know as Lady Nesardo.
Salene appears in the book Diablo: Moon of the Spider.